Last edited by Tazragore
Saturday, July 11, 2020 | History

8 edition of Gap Junctions in Development and Disease found in the catalog.

Gap Junctions in Development and Disease

by Elke Winterhager

  • 80 Want to read
  • 35 Currently reading

Published by Springer .
Written in English

    Subjects:
  • Cellular biology,
  • Medical,
  • Science,
  • Life Sciences - Biology - General,
  • Brain Development,
  • Carcinogenesis,
  • Cardiac Development,
  • Connexin,
  • Folliculogenesis,
  • Science / Biology,
  • Biochemistry,
  • Dermatology,
  • Connexins,
  • Gap junctions (Cell biology),
  • genetics

  • The Physical Object
    FormatHardcover
    Number of Pages279
    ID Numbers
    Open LibraryOL12773623M
    ISBN 103540261567
    ISBN 109783540261568

    This book is the first of its kind to highlight the recent progress in understanding gap junction structure, and discuss the specific roles of individual connexins. It brings together an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and. These junctions influence the shape and folding of the epithelial tissue. In contrast with the tight and anchoring junctions, a gap junction forms an intercellular passageway between the membranes of adjacent cells to facilitate the movement of small molecules and ions between the cytoplasm of adjacent cells.

      The reader interested in gap junctions and disease is referred to the recent volume edited by Peracchia, particularly chapters 20 and 22 (Gap Junctions: Molecular Basis of Cell Communication in Health and Disease—Volume Current Topics in Membranes, C. Peracchia, ed., Academic Press, San Diego, CA, ).Author: Linda Musil. Nevertheless, via gap junctions the slow response action potentials elicited in the sinoatrial nodal cells will trigger fast response action potentials in adjacent myocytes and then those within the remainder of the atria (Figure 6). In a healthy heart, it takes approximately 30 msec for excitation to spread between the sinoatrial and.

    Gap junctions allow the exchange of ions, second messengers, and small metabolites between adjacent cells and are formed by two unrelated protein families, the pannexins and connexins. Mutations in connexin genes cause a variety of genetic disorders, implicating a critical role in tissue homeostasis. Association of congenital skin disorders to mutations in different Cited by: Third, given that gap junctions are known to play important roles in retinal development (), and may affect susceptibility to disease pathologies (), it will be important to examine whether gap junctions play precise cell-type-specific roles in development () and disease.


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Gap Junctions in Development and Disease by Elke Winterhager Download PDF EPUB FB2

The main objective of Gap Junctions in Development and Disease is to describe the molecular events that cause impairments in development and disease.

Communication between cells via intercellular channels, so called gap junctions, appears to be essential for certain developmental processes and appropriate organ function.

The main objective of Gap Junctions in Development and Disease is to describe the molecular events that cause impairments in development and disease.

Communication between cells via intercellular channels, so called gap junctions, appears to be essential for certain developmental processes and appropriate organ : Hardcover. "The main objective of Gap Junctions in Development and Disease is to describe the molecular events that cause impairments in development and disease.

Communication between cells via intercellular channels, so called gap junctions, appears to be essential for certain developmental processes and appropriate organ function.

Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease.

Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness.

One gap junction channel is composed of two connexons (or hemichannels), which connect across the intercellular space.

Gap junctions are analogous to the plasmodesmata that join plant cells. Gap junctions occur in virtually all tissues of the body, with the exception of adult fully developed skeletal muscle and mobile cell types such as sperm or : Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease.

Request PDF | Gap Junctions in Development and Disease | The emergence of multicellular organisms has necessitated the specialization of short- and long-range chemical signaling systems, including.

Get this from a library. Cell junctions: adhesion, development, and disease. [Susan E LaFlamme; Andrew Kowalczyk;] -- The first comprehensive book on this topic of fundamental importance in our understanding of cancer begins with an overview of cellular junctions, before covering cell-matrix junctions, cell-cell.

Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular : Hardcover.

The term gap junction is derived from the notion that they act as transmembrane channels (connexons) whereby the interacting plasma membranes are separated by a gap of about 3 nm.

The function of gap junctions is dealt with in this book entitled Gap Junctions in Development and Disease (edited by Elke Winterhager).Author: Hans Bloemendal.

Several studies have noted the involvement of gap junctions in CNS disorders, including cerebrovascular diseases such as brain ischemia and brain hemorrhage, neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, epilepsy, and brain tumors.

In this review, possible functions of gap junctions and hemichannels Cited by:   This long-awaited, first comprehensive book on this topic of fundamental importance in our understanding of cancer begins with an overview of cellular junctions, before covering cell-matrix junctions, cell-cell junctions and cell.

Alterations in gap junctions and connexin expression in heart disease. The established role of gap junctions as the cell-to-cell pathways for the orderly spread of current flow required for synchronous contraction in the healthy heart led to the question being posed as to whether alterations of gap junction organization and connexin expression Cited by: Gap Junction and Connexin Remodeling in H uman Heart Disease 77 Barker RJ, Price RL, Gourdie RG () Increased association of ZO-1 with connexin43 during remodeling of.

Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, Author: Ekrem Dere.

This book is the first to highlight the recent progress in understanding gap junction structure and to discuss the specific roles of individual connexins. It features contributions from an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and.

In this Review, the authors discuss the role of connexins, hemichannels and gap junctions in musculoskeletal tissues and rheumatic diseases. Connexons form the basis of hemichannels and gap by:   Purchase Gap Junctions: Molecular Basis of Cell Communication in Health and Disease, Volume 49 - 1st Edition.

Print Book & E-Book. ISBNBook Edition: 1. This long-awaited, first comprehensive book on this topic of fundamental importance in our understanding of cancer begins with an overview of cellular junctions, before covering cell-matrix junctions, cell-cell junctions and cell-matrix and cell-cell adhesion in separate sections.

Of high Price: $ His main research interest is on the role of gap junctions in the pathogenesis of NeuroAIDS but his studies have recently branched into the effects of HIV infection on gap junction protein expression within cardiomyocytes and how HIV modulates their function to contribute to the development of cardiovascular disease in people living with HIV.

Erratum in Am J Med Genet C Semin Med Genet. Feb 15;(1) Gap junctions are intercellular channels that allow the passage of water, ions, and small molecules.

They are involved in quick, short-range messaging between cells and are found in skin, nervous tissue, heart, and muscle. An Cited by: The aim of the present article is to review our current knowledge on the structure, regulation, function, and pharmacology of gap junctions.

This will be supported by examples of how different connexins and their regulation act in concert to achieve appropriate physiological control, and how disturbances of connexin function can lead to disease. Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular : Ekrem Dere.